Reversible uranyl fluoride nephrotoxicity in the Long Evans rat

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Fundamental and Applied Toxicology; (USA)

DOI:https://doi.org/10.1016/0272-0590(89)90307-2· OSTI ID:5466357

Diamond, G L; Morrow, P E; Panner, B J; Gelein, R M; Baggs, R B ^[1]

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1. Univ. of Rochester, NY (USA)

Severity and duration of renal injury produced by low levels of uranyl fluoride (UO2F2) were examined in the rat. Rats received multiple ip injections of UO2F2 (cumulative dose: 0.66 or 1.32 mg U/kg body wt). Renal injury was characterized histologically by cellular and tubular necrosis of pars recta of proximal tubule (S2 and S3), with less severe cellular injury to thick ascending limb of loop of Henle and collecting tubule. Injury was evident when renal uranium levels were between 0.7 and 1.4 micrograms U/g wet kidney and was most severe when renal uranium burden was between 3.4 and 5.6 micrograms U/g. Repair of injury was rapid, with complete restoration within 35 days after exposure. Associated with injury were abnormalities in renal function, including impaired tubular reabsorption, proteinuria, and enzymuria, which appeared temporally related, to variable degrees, to progression of renal injury. Thus, reversible renal injury occurs in the rat at levels of uranium in kidney below the present Nuclear Regulatory Commission standard of 3 micrograms U/g kidney for renal injury in humans.

• OSTI ID: 5466357
• Journal Information: Fundamental and Applied Toxicology; (USA), Journal Name: Fundamental and Applied Toxicology; (USA) Vol. 13:1; ISSN 0272-0590; ISSN FAATD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ALDEHYDES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
BODY BURDEN
CARBOHYDRATES
CREATININE
DISEASES
FLUORIDES
FLUORINE COMPOUNDS
GLUCOSE
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HEXOSES
IMIDAZOLES
IMINES
IRRADIATION
KIDNEYS
LOW DOSE IRRADIATION
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOINDUCTION
RATS
RECOVERY
REPAIR
RODENTS
SACCHARIDES
TOXICITY
URANIUM COMPOUNDS
URANYL COMPOUNDS
URANYL FLUORIDES
UROGENITAL SYSTEM DISEASES
VERTEBRATES
WEIGHT