Nephrotoxicity of uranyl fluoride and reversibility of reval injury in the rat

Technical Report · Tue Sep 01 04:00:00 EDT 1987

OSTI ID:6087457

Diamond, G L; Gelein, R M; Morrow, P E; Panner, B J; Baggs, R B

This study examined the severity and duration of renal injury produced in the rat from exposure to low levels of uranyl fluoride (UO/sub 2/F/sub 2/). Rats received multiple i.p. injections of UO/sub 2/F/sub 2/ (cumulative dose: 0.66 or 1.32 mg U/kg body wt). Renal injury was characterized primarily by cellular and tubular necroses of the pars recta of the proximal tubule (S/sub 2/ and S/sub 3/), with less severe cellular injury to the thick ascending limb of the loop of Henle and collecting tubule. The injury was apparent early in the dosing phase of the study, at a time when renal uranium levels were between 0.7 to 1.4 ..mu..g U/g, and was most severe when the renal uranium burden was between 3.4 to 5.6 ..mu..g U/g. Repair of the injury was rapid, with complete restoration within 35 days after the exposure. Associated with the injury were numerous abnormalities in kidney function, including impaired tubular reabsorption, proteinuria and enzymuria, which appeared to be temporally related, to variable degrees, to the progression of renal injury. Thus, reversible renal injury occurred in the rat at levels of uranium in kidney below the proposed threshold standard for renal injury in humans of 3 ..mu..g U/g kidney. However, renal injury preceded and outlasted functional abnormalities as assessed by urinalysis and clearance measurements. 28 refs., 35 figs., 7 tabs.

• Research Organization: Rochester Univ., NY (USA). School of Medicine and Dentistry; Nuclear Regulatory Commission, Washington, DC (USA). Div. of Regulatory Applications
• OSTI ID: 6087457
• Report Number(s): NUREG/CR-4951; ON: DE87900991
• Country of Publication: United States
• Language: English

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560161* -- Radionuclide Effects
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
FLUORIDES
FLUORINE COMPOUNDS
GROWTH
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
MAMMALS
NECROSIS
ORGANS
PATHOLOGICAL CHANGES
RADIOSENSITIVITY
RATS
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
RODENTS
SPECTROPHOTOMETRY
URANIUM COMPOUNDS
URANYL COMPOUNDS
URANYL FLUORIDES
VERTEBRATES