An evaluation of Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) as a rescue agent for the nephropathy induced by uranyl fluoride (UO2F2) in rats

Journal Article · Mon Apr 01 04:00:00 EST 1991 · Research Communications in Chemical Pathology and Pharmacology; (United States)

OSTI ID:5505598

Zalups, R K ^[1]

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1. Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA (USA)

Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) was tested as a potential rescue agent for the nephropathy induced by uranyl fluoride (UO2F2) in rats. When uranyl fluoride was administered (i.v.) to male Sprague-Dawley rats at a dose that delivered 250 micrograms U/kg, moderate to severe cellular necrosis occurred in pars recta segments of proximal tubules in the cortex and outer stripe of the outer medulla of the rats' kidneys within four days after treatment. The severity of renal tubular injury was not significantly diminished when rats were given a 10, 100 or 1,000 mg/kg dose of Tiron (i.p.) 30 minutes after the administration of uranyl fluoride. No obvious protection was noted even when the rats were given a 1,000 mg/kg dose of Tiron 15, 30 and 90 minutes after the administration of uranyl fluoride. Therefore, Tiron does not appear to provide rats substantial protection against a dose of uranyl fluoride that induces moderate to severe renal injury.

• OSTI ID: 5505598
• Journal Information: Research Communications in Chemical Pathology and Pharmacology; (United States), Journal Name: Research Communications in Chemical Pathology and Pharmacology; (United States) Vol. 72:1; ISSN RCOCB; ISSN 0034-5164
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
AROMATICS
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RATS
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SODIUM COMPOUNDS
SULFONIC ACIDS
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URANIUM COMPOUNDS
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