Toxic interactions among Pb, Zn, and Cd with varying levels of dietary Ca and vitamin D: hematological system
Journal Article
·
· Environ. Res.; (United States)
Rats were fed lead (0.5 percent), zinc (0.63 percent), cadmium (90 ppM), and control diets individually and in combinations with each other. These diets were fed for 42 days with two levels of calcium (0.1 and 0.9 percent) and three levels of vitamin D (0, 2000, and 50,000 IU/kg of feed). The most significant findings were: a more severe anemia when zinc and cadmium were fed together than when fed individually; a marked reduction of a lead-induced reticulocytosis when toxic zinc or cadmium diets were fed; a reduction of urine delta-aminolevulinic acid levels by the administration of excess zinc to lead-fed rats, or when excess cadmium was fed in low vitamin D diets; and the low serum iron levels of zinc toxicity were further reduced by low calcium or high vitamin D diets.
- Research Organization:
- Univ. of Guelph, Ont.
- OSTI ID:
- 5204472
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 14:3; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
AMINO ACIDS
AMINOLEVULINIC ACID
ANEMIAS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY FLUIDS
CADMIUM
CALCIUM
CARBOXYLIC ACIDS
DIET
DISEASES
ELEMENTS
ERYTHROCYTES
HEMATOLOGY
HEMIC DISEASES
IRON
LEAD
MAMMALS
MEDICINE
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RATS
RESPONSE MODIFYING FACTORS
RETICULOCYTES
RODENTS
SYMPTOMS
SYNERGISM
TRANSITION ELEMENTS
VERTEBRATES
VITAMIN D
VITAMINS
ZINC
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
AMINO ACIDS
AMINOLEVULINIC ACID
ANEMIAS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY FLUIDS
CADMIUM
CALCIUM
CARBOXYLIC ACIDS
DIET
DISEASES
ELEMENTS
ERYTHROCYTES
HEMATOLOGY
HEMIC DISEASES
IRON
LEAD
MAMMALS
MEDICINE
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RATS
RESPONSE MODIFYING FACTORS
RETICULOCYTES
RODENTS
SYMPTOMS
SYNERGISM
TRANSITION ELEMENTS
VERTEBRATES
VITAMIN D
VITAMINS
ZINC