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DNA repair in human fibroblasts treated with a combination of chemicals

Journal Article · · Biophys. J.; (United States)
;
Excision repair of DNA damage was measured by the photolysis of bromodeoxyuridine incorporated during repair in normal human and xeroderma pigmentosum group C fibroblasts (XP C) treated with a combination of the carcinogens N-acetoxy-2-acetylamino fluorene (AAAF), and 4-nitroquinoline 1-oxide (4NQO). Repair was additive in normal and XP C cells treated with AAAF plus 4NQO, indicating that there are different rate limiting steps for removal of 4NQO and AAAF lesions.
Research Organization:
Brookhaven National Lab., Upton, NY
OSTI ID:
6192025
Journal Information:
Biophys. J.; (United States), Journal Name: Biophys. J.; (United States) Vol. 35:1; ISSN BIOJA
Country of Publication:
United States
Language:
English

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Related Subjects

550200* -- Biochemistry
560112 -- Radiation Effects on Biochemicals-- In Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BROMOURACILS
BUDR
CARCINOGENESIS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DECOMPOSITION
DISEASES
DNA
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
MAN
MORPHOLOGICAL CHANGES
MUTAGENESIS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PHOTOCHEMICAL REACTIONS
PHOTOLYSIS
PRIMATES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RIBOSIDES
SKIN DISEASES
SOMATIC CELLS
ULTRASTRUCTURAL CHANGES
ULTRAVIOLET RADIATION
URACILS
VERTEBRATES
XERODERMA PIGMENTOSUM