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Comparison of the protective action of glutathione and cysteamine on radiation-induced mitotic delay in cultured L-5 cells

Conference · · Radiology; (United States)
OSTI ID:6187784
; ; ;
The protective effect of glutathione (GSH) and cysteamine (MEA) on radiation-induced mitotic delay in cultured mammalian L-5 cells was studied. Cells treated with 20 mM of GSH during irradiation with 2 Gy (200 rad) showed faster recovery of the mitotic index than control cells irradiated without chemical treatment; however, GSH had no effect on mitotic delay time. Inhibition of mitosis was observed with 80, 100, and 120 mM of GSH. Cells treated with 5 mM of MEA during irradiation also showed faster recovery of the mitotic index than the controls, but in addition the delay time was shortened. Progression of G/sub 2/-phase cells treated with 5-fluorouracil to mitosis after irradiation was protected by MEA but not by GSH. Progression of S-phase cells labeled with /sup 3/H-thymidine to mitosis was accelerated by both agents during irradiation.
OSTI ID:
6187784
Conference Information:
Journal Name: Radiology; (United States) Journal Volume: 131:3
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL CYCLE
DRUGS
ELECTROMAGNETIC RADIATION
GLUTATHIONE
IN VITRO
IONIZING RADIATIONS
IRRADIATION
L CELLS
MEA
MITOTIC DELAY
MITOTIC INDEX
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
SYNCHRONOUS CULTURES
THIOLS
X RADIATION