Effects of glutathione on mitotic delay induced by x irradiation in Ehrlich ascites tumor cells. II

Journal Article · Fri Jun 01 04:00:00 EDT 1973 · Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 6, pp. 541-545

OSTI ID:4409749

Kawasaki, S; Sakurai, K

The radioprotective action of glutathione(GSH) was studied at the cytological level using the mitotic index of Ehrlich ascites tunnor cells. Glutathione 130 mg/mouse) was administered intraperitoneally 30 min and 3 and 6 hrs before irradiation with 400 rad. Glutathione accelerated the recovery of mitosis after irradiation. The action was most intense when it was administered 30 min before irradiation, followed by the administration 3 and 6 hrs before irradiation. Thirty minutes, 3 hrs, 6 hrs, and 9 hrs after irradiation with 400 rad, glutathione 130 mg/mouse) was administered intraperitoneally. When glutathione was administered after irradiation, the reappearance of mitotic cells was inhibited. Such inhibition was most intense when it was given 3 hrs after irradiation. Changes of mitotic index after administration of glutathione 10, 5, 10, 20, 30, and 40 mg/mouse) alone were observed. The mitotic index in the groups with the administration 20 to 40 mg of glutathione showed a slight decrease until 6 hrs after administration, and then showed a marked increase 12 to 15 hrs after administration. On the basis of these data, the mechanisms of the radioprotective action of glutathione are discussed. (auth)

• Research Organization: Yamaguchi Univ., Ube, Japan
• NSA Number: NSA-29-010431
• OSTI ID: 4409749
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 6, pp. 541-545, Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 6, pp. 541-545; ISSN NHGZA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*ASCITES TUMOR CELLS-- MITOTIC INDEX
*GLUTATHIONE-- RADIOSENSITIVITY EFFECTS
*MITOTIC DELAY-- RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
DOSE-RESPONSE RELATIONSHIPS
EHRLICH ASCITES TUMOR
IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
X RADIATION