Effects of glutathione on mitotic delay induced by x irradiation in Ehrlich ascites tumor cells. I

Journal Article · Fri Jun 01 04:00:00 EDT 1973 · Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 6, pp. 535-540

OSTI ID:4392487

Kawasaki, S; Sakurai, K

The radioprotective action of glutathione (GSH) was studied at the cytological level using the mitotic index of Ehrlich ascites tumor cells. After irradiation with 100 and 200 rad, the rate of recovery of mitotic index in the group treated with 30 mg CSH was similar to that in the control group. But 12 hours after irradiation and on, the mitotic index increased more than the value of the control. With 400 and 600 rad, the recovery of the mitotic index was accelerated by the pretreatment with 30 mg GSH. Treatment with GSH alone induced a slight decrease in the mitotic index and later a marked increase at 9 to 12 hours. These data might suggest that the action of GSH is related to the cell cycle. (auth)

• Research Organization: Yamaguchi Univ., Ube, Japan
• NSA Number: NSA-29-010430
• OSTI ID: 4392487
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 6, pp. 535-540, Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 6, pp. 535-540; ISSN NHGZA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*ASCITES TUMOR CELLS-- MITOTIC INDEX
*GLUTATHIONE-- RADIOSENSITIVITY EFFECTS
*MITOTIC DELAY-- RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
DOSE-RESPONSE RELATIONSHIPS
EHRLICH ASCITES TUMOR
IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
X RADIATION