Effects of WR 2721 on cyclic nucleotide levels and lysosomal enzyme activities
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The radioprotectant WR 2721 administered intraperitoneally to rats at 30-40 min before exposure to 1000 rad of /sup 60/Co caused a reduction in spleen lysosomal enzyme activity and fluctuations in cyclic nucleotide levels. Liver and spleen cAMP levels from drug-treated animals were higher at 3-6 hr postirradiation whereas spleen cGMP levels were lower at 1-4 hr postirradiation than irradiated controls not given the radioprotectant. At 3 days after radiation exposure, spleen cyclic nucleotide levels and lysosomal enzyme activities in rats given WR 2721 were closer to the level of nonirradiated control rats than of irradiated rats receiving saline.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD
- OSTI ID:
- 7067411
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMP
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CONSTITUENTS
COBALT 60
COBALT ISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
GAMMA RADIATION
GLYCOSYL HYDROLASES
HYDROLASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYSOSOMES
LYSOZYME
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOTIDES
O-GLYCOSYL HYDROLASES
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
THIOIC ACIDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMP
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CONSTITUENTS
COBALT 60
COBALT ISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
GAMMA RADIATION
GLYCOSYL HYDROLASES
HYDROLASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYSOSOMES
LYSOZYME
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOTIDES
O-GLYCOSYL HYDROLASES
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
THIOIC ACIDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES