Variation in cyclic nucleotide levels and lysosomal enzyme activities in the irradiated rat

Journal Article · Mon Sep 01 00:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575345· OSTI ID:6881585

Trocha, P J; Catravas, G N

Whole-body irradiation of rats causes not only a release of hydrolases from the lysosomes but also fluctuations in the cyclic nucleotide levels in spleen and liver tissues. Significant increases in lysosomal enzyme activities were further observed in spleen following radiation treatment. At 3 to 6 hr after rats were exposed to ..gamma.. radiation, transient increases in both cGMP and cAMP levels were accompanied with the release of ..beta..-glucuronidase and acid phosphatase enzymes from lysosomes in liver and spleen tissues. A second transitory release and activation of lysosomal hydrolases and an increase in cAMP levels occurred between 2 and 5 days after irradiation in spleen but not in liver. On Days 7 and 8, there was a third release of lysosomal hydrolases and a slight increase in the spleen cAMP concentration before they returned to near-control values. Cyclic GMP levels in the spleen decreased on the third day after irradiation, remained suppressed until Day 9, and then increased to levels higher than normal physiological values. The liver cGMP concentration remained unchanged between 9 hr and 11 days after irradiation.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD
• OSTI ID: 6881585
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
AMP
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CONSTITUENTS
COBALT 60
COBALT ISOTOPES
DATA
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
ESTERASES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
GLANDS
GLUCURONIDASE
GLYCOSYL HYDROLASES
GUANOSINE
HETEROCYCLIC COMPOUNDS
HYDROLASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIVER
LYSOSOMES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
O-GLYCOSYL HYDROLASES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHATASES
PHOSPHATES
PHOSPHORUS COMPOUNDS
PURINES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
RIBOSIDES
RODENTS
SPLEEN
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES