Effect of caffeine on radiation-induced mitotic delay: delayed expression of G/sub 2/ arrest
Journal Article
·
· Radiat. Res.; (United States)
In the presence of 5 mM caffeine, irradiated (1.5 Gy) S and G/sub 2/ cells progressed to mitosis in register and without arrest in G/sub 2/. Caffeine (5 mM) markedly reduced mitotic delay even after radiation doses up to 20 Gy. When caffeine was removed from irradiated (1.5 Gy) and caffeine-treated cells, a period of G/sub 2/ arrest followed, similar in length to that produced by radiation alone. The arrest expressed was independent of the duration of the caffeine treatment for exposures up to 3 hr. The similarity of the response to the cited effects of caffeine on S-phase delay suggests a common basis for delay induction in S and G/sub 2/ phases.
- Research Organization:
- Thomas Jefferson Hospital, Philadelphia, PA
- OSTI ID:
- 5211780
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 97:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Conference
·
Fri Jun 01 00:00:00 EDT 1979
· Radiology; (United States)
·
OSTI ID:6187784
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Increased expression of cyclin B1 mRNA coincides with diminished G{sub 2}-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine
Journal Article
·
Wed Nov 30 23:00:00 EST 1994
· Radiation Research
·
OSTI ID:50632
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANALEPTICS
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
CAFFEINE
CELL CYCLE
CELL DIVISION
CENTRAL NERVOUS SYSTEM AGENTS
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
HAMSTERS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MITOSIS
MITOTIC DELAY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
VERTEBRATES
X RADIATION
XANTHINES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANALEPTICS
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
CAFFEINE
CELL CYCLE
CELL DIVISION
CENTRAL NERVOUS SYSTEM AGENTS
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
HAMSTERS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MITOSIS
MITOTIC DELAY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
VERTEBRATES
X RADIATION
XANTHINES