Mechanism of enteroviral inactivation by ozone

Journal Article · Sun Mar 01 04:00:00 EST 1981 · Appl. Environ. Microbiol.; (United States)

OSTI ID:6170636

Roy, D; Wong, P K; Engelbrecht, R S; Chian, E S

The mechanism of enteroviral inactivation by ozone was investigated with poliovirus 1 (Mahoney) as the model virus. Ozone was observed to alter two of the four polypeptide chains present in the viral protein coat of poliovirus 1. However, the alteration of the protein coat did not significantly impair virus adsorption or alter the integrity of the virus particle. Damage to the viral RNA after exposure to ozone was demonstrated by velocity sedimentation analysis. It was concluded that the damage to the viral nucleic acid is the major cause of poliovirus 1 inactivation by ozone.

• Research Organization: Univ. of Illinois, Urbana
• OSTI ID: 6170636
• Journal Information: Appl. Environ. Microbiol.; (United States), Journal Name: Appl. Environ. Microbiol.; (United States) Vol. 41:3; ISSN AEMID
• Country of Publication: United States
• Language: English

Related Subjects

550700 -- Microbiology
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
CENTRIFUGATION
INACTIVATION
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
OZONE
PARASITES
PEPTIDES
POLIO VIRUS
POLYPEPTIDES
PROTEINS
RNA
SEPARATION PROCESSES
ULTRACENTRIFUGATION
VIRUSES