Mechanism of poliovirus inactivation by ammonia
Journal Article
·
· J. Virol.; (United States)
OSTI ID:5140781
Poliovirus inactivation by ammonia causes a slight reduction in the sedimentation coefficients of viral particles, but has no detectable effect on either the electrophoretic pattern of viral capsid proteins or the isoelectric points of inactivated particles. These virions still attach to cells, but are unable to repress host translation or stimulate the synthesis of detectable amounts of viral RNA. Although ammonia has no detectable effect on naked poliovirus RNA, it causes cleavage of this RNA when still within viral particles. Therefore, the RNA genome appears to be the only component of poliovirus significantly affected by ammonia.
- Research Organization:
- Sandia Labs., Albuquerque, NM
- OSTI ID:
- 5140781
- Journal Information:
- J. Virol.; (United States), Journal Name: J. Virol.; (United States) Vol. 26:2; ISSN JOVIA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mechanisms of poliovirus inactivation by the direct and indirect effects of ionizing radiation
Methods to inactivate enteric viruses in wastewater sludge
Inactivation of poliovirus in digested sludge
Journal Article
·
Fri Aug 01 00:00:00 EDT 1980
· Radiat. Res.; (United States)
·
OSTI ID:6817801
Methods to inactivate enteric viruses in wastewater sludge
Technical Report
·
Tue Feb 28 23:00:00 EST 1978
·
OSTI ID:5042691
Inactivation of poliovirus in digested sludge
Journal Article
·
Tue Jun 01 00:00:00 EDT 1976
· Appl. Environ. Microbiol.; (United States)
·
OSTI ID:7342734
Related Subjects
550700 -- Microbiology
552000 -- Public Health
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AMMONIA
BIOLOGICAL EFFECTS
HYDRIDES
HYDROGEN COMPOUNDS
INACTIVATION
INHIBITION
MICROORGANISMS
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
POLIO VIRUS
RNA
VIRUSES
552000 -- Public Health
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AMMONIA
BIOLOGICAL EFFECTS
HYDRIDES
HYDROGEN COMPOUNDS
INACTIVATION
INHIBITION
MICROORGANISMS
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
POLIO VIRUS
RNA
VIRUSES