Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children

Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90015-8· OSTI ID:6141892

Holcenberg, J S ^[1]; Kun, L E; Ring, B J; Evans, W E

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1. Medical Coll. of Wisconsin, Milwaukee

The effect of hepatic irradiation on adriamycin toxicity and pharmacokinetics was studied in 10 children who received adriamycin with concurrent abdominal irradiation for Wilms' tumor. Hepatic irradiation to 2400 to 2700 rad at 100 to 150 rad per fraction did not alter the clinical toxicity or plasma pharmacokinetics of adriamycin.

• OSTI ID: 6141892
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
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PHARMACOLOGY
RADIOSENSITIVITY EFFECTS
LEUKOPENIA
RADIOINDUCTION
NAUSEA
RADIOTHERAPY
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GLANDS
HEMIC DISEASES
IRRADIATION
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NUCLEAR MEDICINE
ORGANS
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560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)