Late orthopedic effects in children with Wilms' tumor treated with abdominal irradiation
- Univ. of Pennsylvania School of Medicine, Philadelphia (USA)
Between 1970 and 1984, 31 children with biopsy-proven Wilms' tumor received nephrectomy, chemotherapy, and abdominal irradiation and were followed beyond skeletal maturity. Three patients (10%) developed late orthopedic abnormalities requiring intervention. Ten children received orthovoltage irradiation, and all cases requiring orthopedic intervention or developing a scoliotic curve of greater than 20 degrees were confined to this group, for a complication frequency of 50%. Those children who developed a significant late orthopedic abnormality (SLOA) as defined were treated to a higher median dose (2,890 cGy) and a larger field size (150 cm2) than those who did not (2,580 cGy and 120 cm2). Age at irradiation, sex, and initial stage of disease did not appear to influence the risk of developing an SLOA. No child who received megavoltage irradiation developed an SLOA despite treatment up to 4,000 cGy or to field sizes of 400 cm2. We conclude that modern radiotherapy techniques rarely lead to significant late orthopedic abnormalities previously associated with abdominal irradiation in children with Wilms' tumor.
- OSTI ID:
- 5321386
- Journal Information:
- Medical and Pediatric Oncology; (United States), Journal Name: Medical and Pediatric Oncology; (United States) Vol. 19:4; ISSN 0098-1532; ISSN MPOND
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHILDREN
COMBINED THERAPY
DELAYED RADIATION EFFECTS
DISEASES
DOSES
INJURIES
KIDNEYS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
THERAPY