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Offspring of patients treated for unilateral Wilms' tumor in childhood

Journal Article · · Cancer (Philadelphia); (United States)
; ;
Twenty-seven women and the wives of nine men who survived unilateral Wilms' tumor in childhood had a total of 59 live born offspring. Among the 33 infants born to women who had received orthovoltage abdominal irradiation, ten weighed less than 2500 g at birth and three died during the perinatal period. In addition, one term infant of normal weight died of complications of a breech delivery. Only one of 26 infants born to the wives of Wilms' tumor patients and unirradiated female patients weighed less than 2500 g at birth and none died. The frequency of congenital malformations and spontaneous abortions in this series was not increased, and no offspring has developed cancer. The findings suggest that the risk of Wilms' tumor is low among progeny of survivors of nonfamilial, unilateral lesions. Damage from abdominal irradiation given to girls with Wilms' tumor may predispose them to the subsequent delivery of low birthweight children.
Research Organization:
Division of Pediatric Oncology, Sidney Farber Cancer Institute, Boston, Massachusetts
OSTI ID:
7054638
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 49:11; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
ABORTION
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHILDREN
COMPARATIVE EVALUATIONS
DIAGNOSIS
DISEASES
EXTERNAL IRRADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
INFANTS
IRRADIATION
MEDICAL SURVEILLANCE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
SURVEILLANCE
THERAPY
WEIGHT