Offspring of patients treated for cancer in childhood

Journal Article · Tue May 01 04:00:00 EDT 1979 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6252555

Li, F P ^[1]; Fine, W; Jaffe, N; Holmes, G E; Holmes, F F

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1. Dept. of Health, Education, and Welfare Bethesda, MD

Genetic effects of cancer in childhood were examined among offspring of patients enrolled in the tumor registries of the Sidney Farber Cancer Institute and the Kansas University Medical Center. For 146 patients, 84 women and 62 men, 293 pregnancies were reported after cessation of treatment of diverse neoplasms. The outcomes of 286 completed pregnancies were as follows: 242 live births (1 set of twins), 1 stillbirth, 25 spontaneous abortions, and 19 therapeutic abortions. Seven live-born infants died during the first 2 years of life, a frequency in accord with expectation. Two offspring have developed cancer. One girl and her father had bilateral hereditary retinoblastoma. A second girl developed acute myelocytic leukemia; her mother had received radiotherapy during childhood for a brain tumor. Compared with their cousins and with published figures for the general population, the study progeny had no excess of congenital anomalles or other diseases. Chromosome and immunoglobulin studies of a few offspring did not reveal damage from preconception exposure to cancer chemotherapy and radiotherapy. Findings indicated that large collaborative studies are needed to monitor the offspring of childhood cancer survivors for inherited traits associated with the parental tumors and for mutagenic effects of therapy, particularly intense multimodality treatments.

• OSTI ID: 6252555
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 62:No. 5; ISSN JNCIA
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CHEMOTHERAPY
CHILDREN
CONGENITAL MALFORMATIONS
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
EMBRYOS
FEMALES
FETUSES
GENETIC EFFECTS
HEMIC DISEASES
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
MALES
MALFORMATIONS
MAMMALS
MAN
MEDICINE
MEN
MUTAGENESIS
NEOPLASMS
NUCLEAR MEDICINE
PATHOGENESIS
PATHOLOGICAL CHANGES
PATIENTS
PREGNANCY
PRENATAL IRRADIATION
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
THERAPY
VERTEBRATES
WOMEN