Long-term effects of radiotherapy in childhood and adolescence

Journal Article · Mon Oct 01 04:00:00 EDT 1990 · American Journal of Surgery; (USA)

DOI:https://doi.org/10.1016/S0002-9610(05)80540-9· OSTI ID:6320653

Larson, D L; Kroll, S; Jaffe, N; Serure, A; Goepfert, H ^[1]

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1. Medical College of Wisconsin, Milwaukee (USA)

The records of 50 selected pediatric patients who were treated and followed at M. D. Anderson Cancer Center were reviewed to study the late effects of nonsurgical treatment of cancer in children. There were 26 girls and 24 boys ranging in age between 2 months and 16 years. Patients with head and neck cancer received chemotherapy and radiotherapy for rhabdomyosarcoma (n = 27), retinoblastoma (n = 8), or nasopharynx cancer (n = 2). Median follow-up was 13 years. The most severe side effects were noted in the fields of radiation and included hypoplasia of the jaw, orbit, or hemi-face with varying degrees of atrophy of the overlying soft tissues. A wide range of endocrine, dental, and psychologic abnormalities was also documented. Since 1 in every 1,000 adults older than 20 years today is likely to be a survivor of childhood cancer, recommendations are made for this new class of patients whom the head and neck surgeon will be seeing in the future.

• OSTI ID: 6320653
• Journal Information: American Journal of Surgery; (USA), Journal Name: American Journal of Surgery; (USA) Vol. 160:4; ISSN 0002-9610; ISSN AJSUA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADOLESCENTS
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHEMOTHERAPY
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
HEAD
INJURIES
MEDICAL RECORDS
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
RECOMMENDATIONS
SIDE EFFECTS
THERAPY