Mesothelioma following Wilms' tumor in childhood

Journal Article · Sun Jul 15 04:00:00 EDT 1984 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19840715)54:2<367::AID-CNCR2820540232>3.0.CO;2-Y· OSTI ID:6799889

Antman, K H; Ruxer, Jr, R L; Aisner, J; Vawter, G

A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated with contact with asbestos but has also been reported after radiation exposure. Two patients are reported who developed malignant mesothelioma of the pleura after treatment for Wilms' tumor in childhood. Both received orthovoltage radiation; one patient also received triethylenemelamine (TEM), an alkylating agent closely related to nitrogen mustard, for 5 years. Factors in the development of second tumors are discussed.

• Research Organization: Dana-Farber Cancer Inst., Boston, MA
• OSTI ID: 6799889
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 54:2; ISSN CANCA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ALKYLATING AGENTS
BODY
CHEMOTHERAPY
CHILDREN
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KIDNEYS
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ORGANS
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PLEURA
RADIOINDUCTION
RADIOLOGY
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SEROUS MEMBRANES
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