Breast carcinoma after cancer therapy in childhood

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19830201)51:3<521::AID-CNCR2820510325>3.0.CO;2-U· OSTI ID:6253980

Li, F P; Corkery, J; Vawter, G; Fine, W; Sallan, S E

Among 910 survivors of childhood cancer, four developed infiltrating carcinoma of the breast and another had noninfiltrating breast tumor. Expected frequency was 0.3 cases of breast cancer in the series. The affected women developed breast carcinoma at ages 20, 25 and 38 years, and the men at ages 38 and 39 years, respectively. Each patient had received orthovoltage chest irradiation for treatment of Wilms' tumor or bone sarcoma between seven and 34 years previously, and estimated radiation dose to the breast exceeded 300 rad in each instance. Four patients also received diverse forms of chemotherapy. Survivors of childhood cancer have increased risk of developing breast cancer and should undergo periodic screening, particularly after breast tissue had been irradiated. Individualized radiotherapy planning can help exclude the breasts from treatment fields for some thoracic neoplasms.

• Research Organization: Clinical Epidemiology Branch, National Cancer Institute
• OSTI ID: 6253980
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 51:3; ISSN CANCA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CHEST
COMPARATIVE EVALUATIONS
DELAYED RADIATION EFFECTS
DISEASES
DOSES
GLANDS
KIDNEYS
MAMMARY GLANDS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RECOMMENDATIONS
RISK ASSESSMENT
SIDE EFFECTS
SKELETON
THERAPY