The effect of abdominal radiation on spleen function: A study in children with Wilms' tumor

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Pediatric Hematology and Oncology; (USA)

DOI:https://doi.org/10.3109/08880018609031202· OSTI ID:6320607

Stevens, M; Brown, E; Zipursky, A ^[1]

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1. Hospital for Sick Children, Toronto, Ontario (Canada)

Reports of splenic dysfunction in patients with Hodgkin's disease who received radiation therapy to the spleen raise questions concerning impairment of splenic function and the long-term risk of bacterial sepsis in children who receive abdominal radiation for other diseases. Splenic function was studied in 20 children with Wilms' tumor using a quantitative assessment of vacuolated (pitted) red cells as a measure of reticuloendothelial function. Fourteen children had received abdominal radiation to a field involving the spleen at a median dose of 2000 rads. Their pitted red cells counts were no different from those of 6 children who received therapy without radiation to the spleen or to those of a group of normal children and adults. We conclude that there is no demonstrable long-term impairment of spleen function with radiation doses at or below 2200 rads.

• OSTI ID: 6320607
• Journal Information: Pediatric Hematology and Oncology; (USA), Journal Name: Pediatric Hematology and Oncology; (USA) Vol. 3:1; ISSN PHONE; ISSN 0888-0018
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
AGE GROUPS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CHILDREN
DOSES
ERYTHROCYTES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RETICULOENDOTHELIAL SYSTEM
SIDE EFFECTS
SPLEEN
THERAPY
TISSUES