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Abdominal irradiation in the treatment of Wilms' tumor

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6793741
;
One hundred and fifty-two consecutive children who had Wilms' tumor were treated from 1960 to 1976. This series was analysed to determine the effect of systemic treatment on the incidence of abdominal relapse. Primary treatment included abdominal irradiation in 151 of these patients. Twenty-two patients (14%) had abdominal disease alone or in part at first relapse. For stages I-IV combined, a first abdominal relapse within the irradiated volume occurred in 3/21 patients (14%) who received no systemic treatment; 6/83 patients (7%) who received actinomycin D (AMD) and 1/35 patients (3%) who received AMD and vincristine (VCR). The mean radiation dose, 2400 rad given in 100-125 rad fractions, was essentially constant. Overall two in-field abdominal relapses occurred among 85 patients with stage I or II disease. The optimal radiation dose could not be determined in this retrospective review, but for stages I and II it was not greater than 2400 rad in 24 fractions.
Research Organization:
Ontario Cancer Inst., Canada
OSTI ID:
6793741
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:6; ISSN IOBPD
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
ACTINOMYCIN
AGE GROUPS
ALKALOIDS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHILDREN
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
DISEASES
DOSES
DRUGS
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GLANDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIVER
MAMMALS
MAN
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ONCOVIN
ORGANIC COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PATIENTS
PEDIATRICS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES