Fractionated total body irradiation for metastatic neuroblastoma

Journal Article · Sun Nov 01 00:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90092-4· OSTI ID:5572685

Kun, L E ^[1]; Casper, J T; Kline, R W; Piaskowski, V D

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1. Medical Coll. of Wisconsin, Madison

Twelve patients over one year old with neuroblastoma (NBL) metastatic to bone and bone marrow entered a study of adjuvant low-dose, fractionated total body irradiation (TBI). Six children who achieved a ''complete clinical response'' following chemotherapy (cyclophosphamide and adriamycin) and surgical resection of the abdominal primary received TBI (10 rad/fraction to totals of 100-120 rad/10-12 fx/12-25 days). Two children received concurrent local irradiation for residual abdominal tumor. The intervals from cessation of chemotherapy to documented progression ranged from 2-16 months, not substatially different from patients receiving similar chemotherapy and surgery without TBI. Three additional children with progressive NBL received similar TBI (80-120 rad/8-12 fx) without objective response.

• OSTI ID: 5572685
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BONE MARROW
NEOPLASMS
RADIOTHERAPY
SKELETON
CHEMOTHERAPY
CHILDREN
FRACTIONATED IRRADIATION
METASTASES
PATIENTS
RADIATION DOSES
SURGERY
AGE GROUPS
ANIMAL TISSUES
BODY
DISEASES
DOSES
HEMATOPOIETIC SYSTEM
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)