In vitro modulation of oncogenesis and differentiation by retinoids and tumor promoters
Journal Article
·
· Carcinogenesis (N.Y.); (United States)
OSTI ID:6135851
In recent years it has become increasingly evident that there exists an antagonism between retinoids and tumor promoters in their effect on differentiation and in their influence on normal and neoplastic cells. In this chapter, this antagonism is shown in two systems: (a) The ability of retinoids to inhibit, in rodent fibroblasts, radiation-induced transformation and its promotion by TPA; and (b) The effectiveness of retinoids in antagonizing the inhibitory effect of TPA on differentiation in rat liver epithelial cells. TPA inhibits the production of Vitamin A (retinol) binding proteins (RBP) and Vitamin A can overcome this inhibitory effect. 12 references, 2 figures, 2 tables.
- Research Organization:
- Columbia Univ. Coll. of Physicians and Surgeons, New York, NY
- DOE Contract Number:
- AC02-78EV04733
- OSTI ID:
- 6135851
- Journal Information:
- Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 7; ISSN CRNGD
- Country of Publication:
- United States
- Language:
- English
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Retinoid inhibition of in vitro invasion of human amnion basement membrane by human tumor cells
Retinoid inhibition of in vitro invasion of human amnion basement membrane by human tumor cells
Journal Article
·
Thu Feb 26 23:00:00 EST 1981
· Ann. N.Y. Acad. Sci.; (United States)
·
OSTI ID:6723096
Retinoid inhibition of in vitro invasion of human amnion basement membrane by human tumor cells
Conference
·
Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:7188292
Retinoid inhibition of in vitro invasion of human amnion basement membrane by human tumor cells
Thesis/Dissertation
·
Thu Dec 31 23:00:00 EST 1987
·
OSTI ID:5718685
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
CELL DIFFERENTIATION
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
EPITHELIUM
ESTERS
FIBROBLASTS
GLANDS
IN VITRO
INHIBITION
IONIZING RADIATIONS
LIVER
MAMMALS
MICE
MUTATIONS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANS
PHORBOL ESTERS
PROTEINS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TISSUES
TOXICITY
TUMOR CELLS
VERTEBRATES
VITAMIN A
VITAMINS
X RADIATION
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
CELL DIFFERENTIATION
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
EPITHELIUM
ESTERS
FIBROBLASTS
GLANDS
IN VITRO
INHIBITION
IONIZING RADIATIONS
LIVER
MAMMALS
MICE
MUTATIONS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANS
PHORBOL ESTERS
PROTEINS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TISSUES
TOXICITY
TUMOR CELLS
VERTEBRATES
VITAMIN A
VITAMINS
X RADIATION