The modulating effect of retinoids and a tumor promoter on malignant transformation, sister chromatid exchanges, and Na/K ATPase

Journal Article · Fri Feb 27 04:00:00 EST 1981 · Ann. N.Y. Acad. Sci.; (United States)

DOI:https://doi.org/10.1111/j.1749-6632.1981.tb12750.x· OSTI ID:6723096

Borek, C; Miller, R C; Geard, C R; Guernsey, D; Osmak, R S; Rutledge-Freeman, M; Ong, A; Mason, H

In earlier reports we have shown that a vitamin A analog inhibits radiation-induced transformation in vitro and that retinoids and TPA exert antagonistic effects on vitamin A-binding protein production. Since the tumor promoter TPA has been reported to enhance radiation-induced transformation, it seemed a logical step to follow up these various studies and to investigate whether the antagonism between vitamin A and TPA on cell differentiation in vitro prevails in their effects on radiation-induced transformation in vitro.

• Research Organization: Columbia Univ., New York, NY
• DOE Contract Number: AC02-78EV04733
• OSTI ID: 6723096
• Journal Information: Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States) Vol. 359; ISSN ANYAA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ANIMAL CELLS
ANIMALS
ATP-ASE
CARCINOGENS
CELL DIFFERENTIATION
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DNA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
ENZYMES
ESTERS
FIBROBLASTS
HAMSTERS
HYDROLASES
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
MUTATIONS
NUCLEIC ACIDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
PHORBOL ESTERS
PHOSPHOHYDROLASES
PROMOTERS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TUMOR PROMOTERS
VERTEBRATES
VITAMIN A
VITAMINS
X RADIATION