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Modification of sister chromatid exchanges and radiation-induced transformation in rodent cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and two retinoids

Journal Article · · Cancer Res.; (United States)
OSTI ID:6060504
; ; ; ; ; ; ; ; ;
Modifiction of sister chromatid exchanges and radiation-induced transformation in mouse C3H/10T 1/2 and Syrian hamster embryo cells by the tumor promoter 12-0-tetradecanoylphorbol-13-acetate and two retinoids has been studied. 12-O-tetradecanoylphorbol-13-acetate alone enhances, and retinoids alone reduce radiation-induced transformation. When both compounds were present, the retinoids not only reduced the oncogenic effects of radiation but completely eliminated the promoting effects of 12-O-tetradecanoylphorbol-13-acetate. These results were not paralleled by changes in sister chromatid exchange frequencies.
OSTI ID:
6060504
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 41:2; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENS
CAROTENOIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
EMBRYONIC CELLS
ESTERS
FIBROBLASTS
HYDROCARBONS
MUTATIONS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
PHORBOL ESTERS
PIGMENTS
PROMOTERS
RADIATION EFFECTS
RADIOINDUCTION
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TERPENES
TUMOR PROMOTERS