Failure of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate to enhance sister chromatid exchange mitotic segregation, or expression of mutations in Chinese hamster cells

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · Cancer Res.; (United States)

OSTI ID:6637975

Thompson, L H ^[1]; Baker, R M; Carrano, A V; Brookman, K W

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1. Lawrence Livermore Lab., CA

The potent tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) was tested for its ability (a) to induce sister chromatid exchange, (b) to increase the rate of transition at the adenine phosphoribosyltransferase (aprt) locus from the presumptive heterozygous state (+-) to the homozygous state (-- or -), and (c) to enhance the frequency of mutations expressed after ultraviolet radiation mutagenesis. No significant effect of TPA in any of these experiments was found.

• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6637975
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 40; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
CARCINOGENESIS
CHROMATIDS
CHROMOSOMES
DISEASES
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GENETICS
HAMSTERS
MAMMALS
MUTAGENESIS
MUTATIONS
NEOPLASMS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES