Effect of ionizing radiation on gastric secretion and gastric motility in monkeys

Technical Report · Thu Aug 01 04:00:00 EDT 1985

OSTI ID:6135567

Dorval, E D; Mueller, G P; Eng, R R; Durakovic, A; Conklin, J J

The prodromal syndrome of radiation sickness is characterized by nausea and vomiting but the pathophysiology and the treatment of this entity is largely unknown. The authors investigated this problem by determining the effects of ionizing radiation on gastric function with and without administration of the dopamine antagonist domperidone. They measured gastric electrical control activity (waves per minute), fractional emptying rate (percent per minute), acid output (microequivalents per minute), and plasma levels of immunoreactive Beta-endorphin. Twelve conscious, chair-adapted rhesus monkeys were studied twice before, once immediately after, and once 2 days after a single 800-cGy (800 rads) /sup 60/Co total-body irradiation. In addition to causing vomiting, total-body irradiation transiently suppressed gastric electrical control activity, gastric emptying and gastric secretion, while increasing plasma levels of immunoreactive Beta-endorphin. Domperidone had no effect on vomiting or gastric function either before or after irradiation, but it significantly increased plasma immunoreactive Beta endorphin.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 6135567
• Report Number(s): AD-A-160448/7/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DIGESTIVE SYSTEM
DOPAMINE
DRUGS
ELECTRICAL EQUIPMENT
EQUIPMENT
EXTERNAL IRRADIATION
GASTRIC ACID
GASTROINTESTINAL TRACT
HORMONES
HYDROXY COMPOUNDS
IRRADIATION
MAMMALS
MATERIALS
MONKEYS
NAUSEA
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHENOLS
PITUITARY HORMONES
POLYPHENOLS
PRIMATES
RADIATION EFFECTS
SECRETION
STOMACH
SYMPATHOMIMETICS
SYMPTOMS
VERTEBRATES
WHOLE-BODY IRRADIATION