Effect of ionizing radiation on gastric secretion and gastric motility in monkeys

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · Gastroenterology; (United States)

OSTI ID:5217552

Danquechin Dorval, E; Mueller, G P; Eng, R R; Durakovic, A; Conklin, J J; Dubois, A

The prodromal syndrome of radiation sickness is characterized by nausea and vomiting but the pathophysiology and the treatment of this entity is largely unknown. The authors investigated this problem by determining the effects of ionizing radiation on gastric function with and without administration of the dopamine antagonist domperidone. They measured gastric electrical control activity (waves per minute), fractional emptying rate (percent per minute), acid output (microequivalents per minute), and plasma levels of immunoreactive beta-endorphin. Twelve conscious, chair-adapted rhesus monkeys were studied twice before, once immediately after, and once 2 days after a single 800-cGy (800 rads) /sup 60/Co total body irradiation. In addition to causing vomiting, total body irradiation transiently suppressed gastric electrical control activity, gastric emptying and gastric secretion, while increasing plasma levels of immunoreactive beta-endorphin. Domperidone had no effect on vomiting or gastric function either before or after irradiation, but it significantly increased plasma immunoreactive beta-endorphin.

• Research Organization: Uniformed Services Univ. of the Health Sciences, Bethesda, MD
• OSTI ID: 5217552
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 2; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BODY FLUIDS
COBALT 60
COBALT ISOTOPES
DOSES
DRUGS
ELECTROPHYSIOLOGY
ENDORPHINS
EXTERNAL IRRADIATION
FASTING
GASTRIC ACID
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MONKEYS
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
PHYSIOLOGY
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
SECRETION
SYMPATHOLYTICS
SYMPTOMS
VERTEBRATES
VOMITING
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES