Effect of ionizing radiation on prostaglandin and gastric secretion in rhesus monkeys

Technical Report · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5871340

Dubois, A; Dorval, E D; Steel, L; Fiala, N P; Conklin, J J

Early radiation toxicity is characterized by nausea and vomiting. The authors have previously shown that gastric emptying, gastric motility, and gastric secretion were suppressed after total-body exposure to irradiation. In this studies, the authors evaluated the relation between vomiting and gastric function in nine rhesus monkeys and explored the possible role of prostaglandins (PG) in these phenomena. The concentration of PG in plasma and gastric juice was determined using a standard radioimmunoassay, and gastric-acid output was measured concurrently using a marker dilution technique. The animals were studied in the basal state and after total-body exposure to 800 cGy /sup 60/Co delivered at a rate of 500 cGy/min. Acid output was abolished from 40 min to 2 h after irradiation but had returned to preirradiation levels 2 days later. Plasma PGE2 and PGI2 (as measured by 6-keto-PGE determination) were not significantly modified by irradiation. In contrast, irradiation produced an immediate significant increase (P<0.05) in gastric-juice concentration of PGE2 and PGI2; both had returned to basal levels 2 days later. Thus, an increase in gastric-juice concentration of both PGE2 and PGI2 is associated with the radiation-induced suppression of acid output.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 5871340
• Report Number(s): AD-A-183481/1/XAB; AFRRI-SR-87-10
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
EXTERNAL IRRADIATION
GASTRIC ACID
GASTROINTESTINAL TRACT
IMMUNOASSAY
IMMUNOLOGY
IRRADIATION
ISOTOPE APPLICATIONS
LABORATORY ANIMALS
MATERIALS
NAUSEA
ORGANS
PROSTAGLANDINS
RADIATION EFFECTS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
SECRETION
STOMACH
SYMPTOMS
TOXICITY
TRACER TECHNIQUES
WHOLE-BODY IRRADIATION