Effect of ionizing radiation on prostaglandins and gastric secretion in rhesus monkeys

Technical Report · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5899470

Dubois, A; Dorval, E D; Steel, L; Fiala, N P; Conklin, J J

The radiation induced prodromal syndrome is characterized by nausea and vomiting. Gastric emptying, gastric motility, and gastric secretion were suppressed after total-body exposure to irradiation. The relation between vomiting and gastric function is evaluated, and the possible role of prostaglandins (PG) in these phenomena is explored. The concentration of PG in the plasma and gastric juice was determined using standard radioimmunoassay and gastric-acid output was concurrently measured using a marker dilution techniques in 9 rhesus monkeys. The animals were studied in the basal state and after total-body exposure to 800 cGy /sup 60/Co delivered at a rate of 500 cGy/min. Acid output was abolished from 40 min to 2 hrs after irradiation but had returned to preirradiation levels 2 days later. Plasma PGE2 and PGI2 were not significantly modified by irradiation. In contrast, irradiation produced an immediate increase (p<0.05) in gastric-juice concentration of PGE2 and PGI2; both had returned to basal levels 2 days later. Thus, both PGE2 and PGI2 may be responsible for the immediate suppression of acid output. Observations suggest that measurement of PG concentration in the gastric juice is useful to examine the role of prostaglandins in gastric function.

• Research Organization: Uniformed Services Univ. of the Health Sciences, Bethesda, MD (USA). Dept. of Medicine
• OSTI ID: 5899470
• Report Number(s): AD-A-183232/8/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
DILUTION
GASTRIC ACID
GASTROINTESTINAL TRACT
MATERIALS
NAUSEA
ORGANS
PROSTAGLANDINS
RADIATION EFFECTS
SECRETION
STOMACH
SYMPTOMS