Effects of oleic acid on pulmonary capillary leak and thromboxanes

Journal Article · Fri Jun 01 00:00:00 EDT 1984 · J. Surg. Res.; (United States)

DOI:https://doi.org/10.1016/0022-4804(84)90146-X· OSTI ID:6132788

Olanoff, L S; Reines, H D; Spicer, K M; Halushka, P V

The role of arachidonic acid metabolites in oleic acid-induced lung injury in anesthetized dogs was investigated. Oleic acid was administered as a bolus injection into the pulmonary artery after either indomethacin (10 mg/kg iv) or vehicle. Measurements of hemodynamic parameters, mean systemic (MAP), pulmonary capillary wedge, and pulmonary artery pressures (PAP), cardiac output, arterial blood gases, extravascular lung waters (EVLW) by thermaldye double indicator dilution techniques and plasma immunoreactive thromboxane B2 (iTxB2), by radioimmunoassay were obtained at zero time (baseline) and 20 min following each oleic acid injection. A new noninvasive technique was employed to measure pulmonary capillary protein leak by the scintigraphic analysis of intravenously administered technetium-/sup 99/m radiolabeled human serum albumin (99mTc -HSA) in the cardiac and lung regions. Oleic acid injection caused a significant dose related fall in MAP, arterial pO/sup 2/, and cardiac output, and increases in EVLW and plasma iTxB2 in the vehicle pretreated animals, while mean PAP remained unchanged. In contrast, in the indomethacin pretreated dogs, MAP, EVLW, cardiac output, and plasma iTxB2 levels did not change from baseline values and there was an increase in mean PAP. Pulmonary vascular resistance was significantly elevated in both groups.

• Research Organization: Medical Univ. of South Carolina, Charleston
• OSTI ID: 6132788
• Journal Information: J. Surg. Res.; (United States), Journal Name: J. Surg. Res.; (United States) Vol. 36:6; ISSN JSGRA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BLOOD COAGULATION FACTORS
BLOOD PRESSURE
BLOOD VESSELS
BODY
CAPILLARIES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COAGULANTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
FUNCTIONS
HEART
HEMATOLOGIC AGENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES