Thallium scintigraphy in experimental toxic pulmonary edema: relationship to extravascular pulmonary fluid. [Dogs]
Pulmonary fluid volumes (PBV = lung blood volume; EVLW = extravascular lung water) were examined to define the effects of oleic acid injury and then to examine the relationship between edema formation and accumulation of pulmonary thallium. In six dogs, pulmonary fluid compartments were monitored during the induction of pulmonary injury by oleic acid (0.15 cc/kg i.v.). By 30 min after the injection, EVLW had doubled; it continued to increase slowly for 180 min, whereas PBV declined. In six anesthetized dogs, similar measurements were made in an identical preparation and pulmonary fluid volumes were compared with pulmonary counts derived from sequential thallium scintigrams obtained after the injection of oleic acid. Measures of EVLW and PBV were obtained sequentially along with thallium scintigrams. The authors conclude that sequential thallium scintigrams provide useful information about the degree of change of EVLW over time in a model of noncardiogenic pulmonary edema.
- Research Organization:
- Univ. of California, San Diego
- OSTI ID:
- 6866572
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of oleic acid on pulmonary capillary leak and thromboxanes
Synthetic smoke with acrolein but not HCl produces pulmonary edema
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BODY FLUIDS
VOLUME
LUNGS
SCINTISCANNING
OLEIC ACID
BIOLOGICAL EFFECTS
THALLIUM 201
BIOLOGICAL ACCUMULATION
DOGS
EDEMA
EXPERIMENTAL DATA
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DATA
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
INFORMATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MONOCARBOXYLIC ACIDS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
THALLIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques