Commercial double-indicator-dilution densitometer using heavy water: Evaluation in oleic-acid pulmonary edema

Journal Article · Sun Apr 01 04:00:00 EDT 1990 · Journal of Clinical Monitoring; (USA)

DOI:https://doi.org/10.1007/BF02828285· OSTI ID:7062583

Leksell, L G; Schreiner, M S; Sylvestro, A; Neufeld, G R ^[1]

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1. Univ. of Pennsylvania School of Medicine, Philadelphia (USA)

We evaluated a commercially available, double-indicator-dilution densitometric system for the estimation of pulmonary extravascular water volume in oleic acid-induced pulmonary edema. Indocyanine green and heavy water were used as the nondiffusible and diffusible tracers, respectively. Pulmonary extravascular water volume, measured with this system, was 67% of the gravimetric value (r = 0.91), which was consistent with values obtained from the radioisotope methods. The measured volume was not influenced by changes in cardiac index over a range of 1 to 4 L.min.m2. This system is less invasive than the thermal-dye technique and has potential for repeated clinical measurements of pulmonary extravascular lung water and cardiac output.

• OSTI ID: 7062583
• Journal Information: Journal of Clinical Monitoring; (USA), Journal Name: Journal of Clinical Monitoring; (USA) Vol. 6:2; ISSN JCMOE; ISSN 0748-1977
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BODY
BODY COMPOSITION
CARBOXYLIC ACIDS
DENSITOMETERS
DEUTERIUM
DOMESTIC ANIMALS
DYES
EDEMA
GOATS
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LUNGS
MAMMALS
MEASURING INSTRUMENTS
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-ODD NUCLEI
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHOTOMETERS
RESPIRATORY SYSTEM
RUMINANTS
STABLE ISOTOPES
SYMPTOMS
TRACER TECHNIQUES
VERTEBRATES
WATER