Comparative late effects of x-rays and negative pimesons on the mouse kidney

Journal Article · Thu Nov 01 04:00:00 EST 1979 · Am. J. Pathol.; (United States)

OSTI ID:6119868

Jordan, S W; Yuhas, J M; Key, C R; Hogstrom, K R; Butler, J L; Klingerman, M M

A system is described for comparing various modalities and fractionation schedules of radition by means of their long-term morphologic effects upon the mouse kidney. The comparison system utilitizes a grading scale for histopathologic changes in which a given histologic grade depends upon meeting defined threshold criteria, rather than quantitation of a particular measurement. Renal tubular alterations served as the basis for comparison, since they appeared more reliably defined then glomerular changes. The effective dose-50%, or ED50, was found for x-rays and negative pimesons administered in 1, 2, or 5 fractions. From these data, the relative biologic effectiveness (RBE) of negative pi-mesons with respect to x-rays was determined for each fractionation schedule.

• Research Organization: Univ. of New Mexico, Albuquerque
• OSTI ID: 6119868
• Journal Information: Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 97:2; ISSN AJPAA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BOSONS
DELAYED RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FRACTIONATED IRRADIATION
HADRONS
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
MESONS
MICE
MORPHOLOGICAL CHANGES
ORGANS
PIONS
PIONS MINUS
PSEUDOSCALAR MESONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
RODENTS
VERTEBRATES
X RADIATION