Modification of radiation damage in the canine kidney by hyperthermia: A histologic and functional study
The purpose of the present study was to evaluate the effect of hyperthermia on the histologic and functional response of the canine kidney following bilateral renal irradiation and hyperthermia. A preliminary investigation also documented renal temperature during whole body hyperthermia (WBH). Thirty-six Beagles were randomized to the following 6 treatment groups: control, WBH alone, 10 Gy alone, 10 Gy + WBH, 15 Gy alone, and 15 Gy + WBH. Whole body hyperthermia was used to produce hyperthermia to insure renal temperatures of 42.0 to 42.5C. These temperatures were reached approximately 90 minutes after completion of radiotherapy and were maintained for 60 minutes. Radiation was delivered as a single fraction. Renal histologic and functional changes were assessed at 1, 2, 3, 4, 6, and 9 months posttherapy. A modified Chalkley point count technique was used to estimate renal tubular, interstitial, vascular, and glomerular volumes. Glomerular filtration rate (GFR) which indicates renal function was measured by clearance of {sup m99}Tc-DTPA using a gamma camera. No changes were seen in GFR or renal tissue volumes in control or WBH alone groups. Renal vascular and glomerular volumes were not affected significantly by any combination of hyperthermia and radiation. In all groups receiving radiation, GFR decreased, percent renal tubular volume decreased and interstitial volume increased significantly over time posttherapy. The magnitude of these changes in the functional and histologic response of the kidney and the latency period before expression of this damage was radiation dose-dependent. Hyperthermia did not modify radiation damage in the kidney as measured with functional and histologic endpoints chosen for this study.
- Research Organization:
- North Carolina State Univ., Raleigh, NC (United States)
- OSTI ID:
- 5543541
- Country of Publication:
- United States
- Language:
- English
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560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
CAMERAS
CARBOXYLIC ACIDS
CHELATING AGENTS
DOGS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
DTPA
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
HYPERTHERMIA
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOI