Dependence of RBE on fraction size for negative pi-meson induced renal injury

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90441-7· OSTI ID:6619592

Jordan, S W; Yuhas, J M; Butler, J L.B.; Kligerman, M M

A method is described for quantitation of murine late renal radiation response using histopathologic grading. Effective dose-50 percent (ED/sub 50/) is defined as the radiation dose at which 50% of animals showed renal tubular alterations of a specific histologic grade. The designated histologic grade was selected on the basis of its correlation with renal failure manifested by elevated blood urea nitrogen levels, weight loss and mortality of the experimental animals. Using this system, the ED/sub 50/ was determined for single, two, five, and fifteen (daily) fraction exposures with 300 kVp x rays and negative pi-meson (pion) beams generated at the Los Alamos Meson Physics Facility. The correlation between total radiation dose and the number of fractions was linear for both x ray and pion exposures when plotted on logarithmic coordinates, i.e. this relationship followed a power function. The relative biological effectiveness (RBE) for pions increased from 1.12 for a single dose of 1130 rad, to 2.18 for 15 daily fractions of 145 rad. This latter fraction size approaches that being used in clinical trials, and provides an estimate of the RBE to be expected for kidney injury under conventional treatment protocols.

• Research Organization: Univ. of New Mexico, Albuquerque
• OSTI ID: 6619592
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD CHEMISTRY
BODY
BOSONS
CARBONIC ACID DERIVATIVES
DATA
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
HADRONS
INFORMATION
INJURIES
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
MESONS
MICE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PIONS
PIONS MINUS
PSEUDOSCALAR MESONS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RBE
RODENTS
UREA
VERTEBRATES
X RADIATION