DIFFERENCE IN INJURY MODE, DOSE-RATE DEPENDENCE, AND RBE OF 730-Mev PROTONS, 100-kvp X RAYS, AND 250-kvp X RAYS
Mortality at 6, 12, and 30 days was studied in male Swiss Webster white mice exposed to 730-Mev protons, 200-kvp x rays, and 100-kvp x rays at different dose rates. In the proton-irradiated mice, 8- to 8-day gastrointestinal death predominated at both 100 and 1000 rad/min, and was enhanced at the higher dose rate. In the x-ray exposures, 12to 14-day hematopoietic death predominated and showed a similar dose-rate effect. The RBE for 30-day LD/sub 50/was found to be 0.8; the RBE for 8-day LD/sub 50/was found to be 1.2 at the same dose rate of 100 rad/min. It is suggested that the difference in injury mode may be due to differences in tissue dose distribution. The higher but variable proton RBE for 8-day gut death appears to exhibit the dose-rate effect associated with low-LET exposure. Practical consequences of the dose distribution and dose-rate factors are discussed. (auth)
- Research Organization:
- California. Univ., Berkeley. Donner Lab.; and California. Univ., Berkeley. Lawrence Radiation Lab.
- DOE Contract Number:
- W-7405-ENG-48
- NSA Number:
- NSA-17-038886
- OSTI ID:
- 4657520
- Report Number(s):
- UCRL-11014; CONF-205-2
- Country of Publication:
- United States
- Language:
- English
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