Fraction size, dose and time dependence of x ray induced late renal injury. [Mice]
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Histologic quantitation of renal radiation injury based on an intact mouse model correlates well with loss of renal mass, as measured by the ratio of right to left renal weight, radiation dose, and time after irradiation. Use of the radiation dose at which 50% of animals show renal tubular changes of a specified grade (ED/sub 50/), allows comparison of 1, 5, and 15 fraction exposures. The X-ray dose necessary to effect significant injury (Grade 3 change) by six months after irradiation (ED/sub 50/) was 11.6, 25.7, and 44.0 Gy for single, 5, and 15 fractions, respectively. Isoeffect plots of total radiation dose as a function of fraction number are linear on logarithmic coordinates, indicating that this relationship followed a power function. When plotted as inverse total dose versus dose per fraction, the six month post-irradiation data were linear, but the 12 month data were not. Lack of linearity is not in agreement with the multi-fraction isoeffect linear quadratic model.
- Research Organization:
- Univ. of New Mexico, Albuquerque
- OSTI ID:
- 5354978
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:6; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Dependence of RBE on fraction size for negative pi-meson induced renal injury
Computer-assisted morphometric analysis of renal radiation response
The effect of fractionated doses of radiation on mouse spinal cord
Journal Article
·
Sat Jan 31 23:00:00 EST 1981
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6619592
Computer-assisted morphometric analysis of renal radiation response
Journal Article
·
Wed Sep 01 00:00:00 EDT 1982
· Anal. Quant. Cytol.; (United States)
·
OSTI ID:6186863
The effect of fractionated doses of radiation on mouse spinal cord
Journal Article
·
Mon Sep 20 00:00:00 EDT 1993
· International Journal of Radiation Oncology, Biology and Physics; (United States)
·
OSTI ID:6568866
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
HISTOLOGY
INFORMATION
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
HISTOLOGY
INFORMATION
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
VERTEBRATES
X RADIATION