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Radiation- and drug-induced DNA repair in mammalian oocytes and embryos

Conference ·
OSTI ID:6099217
;

A review of studies showing ultraviolet- or drug-induced unscheduled DNA synthesis in mammalian oocytes and embryos suggests that the female gamete has an excision repair capacity from the earliest stages of oocyte growth. The oocyte's demonstrable excision repair capacity decreases at the time of meiotic maturation for unknown reasons, but the fully mature oocyte maintans a repair capacity, in contrast to the mature sperm, and contributes this to the zygote. Early embryo cells maintain relatively constant levels of excision repair until late fetal stages, when they lose their capacity for excision repair. These apparent changes in excision repair capacity do not have a simple relationship to known differences in radiation sensitivity of germ cells and embryos.

Research Organization:
California Univ., San Francisco (USA)
Sponsoring Organization:
Not Available; USDOE
DOE Contract Number:
EY-76-C-03-1012
OSTI ID:
6099217
Report Number(s):
CONF-790676-5
Country of Publication:
United States
Language:
English

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Related Subjects

560114 -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COMPARATIVE EVALUATIONS
DNA
DNA REPLICATION
DRUGS
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
ESTERS
GAMETES
GERM CELLS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
METHYL METHANESULFONATE
MUTAGENS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
OOCYTES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RECOVERY
REPAIR
SPERMATOZOA
STRAND BREAKS
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
VERTEBRATES
X RADIATION