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Repair of the ultraviolet-irradiated male genome in fertilized mouse eggs

Journal Article · · Science; (United States)
;

Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.

Research Organization:
Univ. of California, San Francisco
OSTI ID:
6792675
Journal Information:
Science; (United States), Journal Name: Science; (United States) Vol. 211; ISSN SCIEA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
MAMMALS
MICE
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES
ZYGOTES