Radiation- and drug-induced DNA repair in mammalian oocytes and embryos

Journal Article · Mon Dec 31 23:00:00 EST 1979 · Basic Life Sci.; (United States)

DOI:https://doi.org/10.1007/978-1-4684-3842-0_27· OSTI ID:5873791

Pedersen, R A; Brandriff, B

A review of studies showing ultraviolet- or drug-induced unscheduled DNA synthesis in mammalian oocytes and embryos suggests that the female gamete has an excision repair capacity from the earliest stages of oocyte growth. The oocyte's demonstrable excision repair capacity decreases at the time of meiotic maturation for unknown reasons, but the fully mature oocyte maintains a repair capacity, in contrast to the mature sperm, and contributes this to the zygote. Early embryo cells maintain relatively constant levels of excision repair until late fetal stages, when they lose their capacity for excision repair. These apparent changes in excision repair capacity do not have a simple relationship to known differences in radiation sensitivity of germ cells and embryos.

• OSTI ID: 5873791
• Journal Information: Basic Life Sci.; (United States), Journal Name: Basic Life Sci.; (United States) Vol. 15; ISSN BLFSB
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
550400* -- Genetics
551000 -- Physiological Systems
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
COMPARATIVE EVALUATIONS
DNA
ELECTROMAGNETIC RADIATION
EMBRYOS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GERM CELLS
MAMMALS
NUCLEIC ACIDS
OOCYTES
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SYNTHESIS
ULTRAVIOLET RADIATION
VERTEBRATES