Repair of uv damage to DNA of implantation-stage mouse embryos in vitro
Journal Article
·
· Exp. Cell Res.; (United States)
Unscheduled DNA synthesis after UV irradiation is demonstrated in late pre-implantation stage and early post-implantation stage mouse embryos by autoradiographic techniques. There was no significant difference in the capacity of morula and blastocyst nuclei to carry out unscheduled DNA synthesis. Irradiated trophoblast nuclei had significantly more grains than irradiated morula or blastocyst nuclei and inner cell mass nuclei had significantly fewer grains. These observations indicate that early mammalian embryos possess enzymes required for excision repair of uv-damaged DNA.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 7322888
- Journal Information:
- Exp. Cell Res.; (United States), Journal Name: Exp. Cell Res.; (United States) Vol. 95:2; ISSN ECREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
EMBRYOS
IRRADIATION
MAMMALS
MICE
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
EMBRYOS
IRRADIATION
MAMMALS
MICE
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES