Lead toxicity and metabolism from lead sulfate fed to Holstein calves

Journal Article · Tue May 01 04:00:00 EDT 1984 · J. Dairy Sci.; (United States)

DOI:https://doi.org/10.3168/jds.S0022-0302(84)81399-5· OSTI ID:6097163

Logner, K R; Neathery, M W; Miller, W J; Gentry, R P; Blackmon, D M; White, F D

Sixteen Holstein intact male calves averaging 85 kg and 74 days of age were assigned randomly to four dietary lead treatments according to body weight. They were fed for ad libitum consumption a control diet containing no added lead or the control diet supplemented with 500, 1500, or 4500 ppm lead as lead sulfate. One calf fed 1500 ppm lead and all four calves fed 4500 ppm lead died within 6 to 10 days after initiation of treatments. Death was sudden with few or no clinical signs prior to death. Those clinical signs that did appear included muscular tremors, gnashing of teeth, bellowing, and convulsions. Four control, four 500 ppm lead, and two 1500 ppm lead-fed calves survived the 7-wk experimental period. Feed consumption, body weight changes, glutamic oxaloacetic transaminase and alkaline phosphatase activity in blood plasma, and hemoglobin were not affected significantly by lead treatments. Packed cell volume in calves fed 500 and 1500 ppm added lead was reduced. Lead concentrations in blood, kidney, liver, bone, brain, and muscle were elevated in lead supplemented calves above those of controls. The highest concentrations of lead were in kidney and liver. 27 references, 6 tables.

• Research Organization: Univ. of Georgia, Athens
• OSTI ID: 6097163
• Journal Information: J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 67:5; ISSN JDSCA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CALVES
CATTLE
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
DEATH
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
GLANDS
INGESTION
INTAKE
KIDNEYS
LEAD
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MUSCLES
NERVOUS SYSTEM
ORGANS
RUMINANTS
SKELETON
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES