Influence of high dietary lead on selenium metabolism in dairy calves

Journal Article · Sat Feb 28 23:00:00 EST 1987 · J. Dairy Sci.; (United States)

DOI:https://doi.org/10.3168/jds.S0022-0302(87)80054-1· OSTI ID:6544287

Neathery, M W; Miller, W J; Gentry, R P; Crowe, C T; Alfaro, E; Fielding, A S; Pugh, D G; Blackmon, D M

Metabolism of orally dosed /sup 75/Se was studied in 10 intact male Holstein calves that were fed ad libitum a control diet containing no added Pb or supplemented with 1000 ppm Pb as PbSO/sub 4/ for 4 wk. Lead-supplemented calves did not exhibit any clinical signs of Pb toxicity. Voluntary feed intake was reduced by 9.5% and average daily gain by 23%. Lead content of rib, liver, and kidney increased. Serum glutamic oxaloacetate transaminase activity was increased during the last 2 wk of the experiment in calves fed Pb. In calves receiving supplemental Pb, /sup 75/Se absorption, blood concentration, and urine concentration were reduced by 26, 21, and 42%, respectively. Tissue /sup 75/Se concentrations were significantly lower in kidney, liver, testicle, pancreas, small intestine, heart, spinal cord, and muscle in calves fed Pb. There was a significant negative correlation (r = -.78) between /sup 75/Se and stable Pb concentrations in the liver. It is not clear whether the ingestion of subclinical amounts of Pb could affect the absorption and utilization of Se in dairy calves to the extent of Se deficiency when dairy calves are kept in areas known to be low in Se.

• Research Organization: Univ. of Georgia, Athens
• OSTI ID: 6544287
• Journal Information: J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 70:3; ISSN JDSCA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
553000 -- Agriculture & Food Technology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CALVES
CATTLE
DAYS LIVING RADIOISOTOPES
DIET
DISTRIBUTION
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GROWTH
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LEAD
MAMMALS
METABOLISM
METALS
NUCLEI
NUTRITIONAL DEFICIENCY
RADIOISOTOPES
RETENTION
RUMINANTS
SELENIUM
SELENIUM 75
SELENIUM ISOTOPES
SEMIMETALS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES