Effects of different levels of dietary lead on zinc metabolism in dairy calves

Journal Article · Wed May 01 00:00:00 EDT 1985 · J. Dairy Sci.; (United States)

DOI:https://doi.org/10.3168/jds.S0022-0302(85)80949-8· OSTI ID:5225816

White, F D; Neathery, M W; Gentry, R P; Miller, W J; Logner, K R; Blackmon, D M

The effects of feeding diets containing 500 or 1500 ppM added lead as lead sulfate on zinc and zinc-65 metabolism in Holstein bull calves were investigated. Zinc absorption was slightly (not significantly) reduced in the calves fed lead. Fecal zinc excretion was increased by the lead diets by day 24 of the experiment. Dietary lead had no significant effect on zinc in blood. Except for the tibia, muscle, and brain, stable zinc decreased in all tissues of calves fed the 1500 ppM lead diets, and differences were significant in pancreas, heart, and testicle. A significant decrease was noted in pancreatic zinc in pancreas of calves fed 500 ppM lead. Tissue zinc-65 concentrations were decreased significantly by lead in the tibia and muscle. Intestinal tissue zinc was not affected materially by lead. Dietary lead had very little effect on cellular distribution of zinc in the liver and kidney. In the mucosal cells of the small intestine, lead increased zinc-65 in the cytosol while decreasing it in the crude nuclear fraction. This effect occurred in a linear fashion in all three sections of the small intestine as dietary lead increased.

• Research Organization: Univ. of Georgia, Athens
• OSTI ID: 5225816
• Journal Information: J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 68:5; ISSN JDSCA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BRAIN
CALVES
CARDIOVASCULAR SYSTEM
CATTLE
CENTRAL NERVOUS SYSTEM
DATA
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
GLANDS
HEART
INFORMATION
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
LEAD
MALE GENITALS
MAMMALS
METABOLISM
METALS
MUSCLES
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ORGANS
PANCREAS
RADIOISOTOPES
RUMINANTS
SKELETON
SMALL INTESTINE
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
ZINC
ZINC 65
ZINC ISOTOPES