Genotoxicity of alpha particles in human embryonic skin fibroblasts
Cell inactivation and induced mutation frequencies at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus have been measured in cultured human fibroblasts (GM10) exposed to ..cap alpha.. particles from /sup 238/ Pu and 250 kVp X rays. The survival curves resulting from exposure to ..cap alpha.. particles are exponential. The mean lethal dose, D/sub 0/, is approximately 1.3 Gy for X rays and 0.25 Gy for ..cap alpha.. particles. As a function of radiation dose, mutation induction at the HGPRT locus was linear for ..cap alpha.. particles whereas the X-ray-induced mutation data were better fitted by a quadratic function. When mutation frequencies were plotted against the log of survival, mutation frequency at a given survival level was greater in cells exposed to ..cap alpha.. particles than to X rays.
- Research Organization:
- Los Alamos National Lab., NM
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6095645
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550401 -- Genetics-- Tracer Techniques
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL KILLING
CHARGED PARTICLES
CONNECTIVE TISSUE CELLS
DATA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
ENZYMES
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
FIBROBLASTS
GLYCOSYL TRANSFERASES
HEAVY NUCLEI
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
INFORMATION
IONIZING RADIATIONS
ISOTOPES
MAMMALS
MAN
MUTATION FREQUENCY
MUTATIONS
NUCLEI
NUMERICAL DATA
ORGANS
PENTOSYL TRANSFERASES
PLUTONIUM 238
PLUTONIUM ISOTOPES
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RBE
SKIN
SOMATIC CELLS
SURVIVAL CURVES
TRANSFERASES
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES