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Mutagenicity and cytotoxicity of 4. 4-MeV. cap alpha. particles emitted by plutonium-238

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574995· OSTI ID:5366423
;

The induction of mutation by ..cap alpha.. particles emitted by plutonium-238 (LET at the cell surface 100 keV/..mu..m) and 250-kVp x rays has been measured utilizing the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in mammalian cells (CHO). Dose-response relationships for mutagenicity and survival of Chinese hamster cell line CHO are presented. Linear plots of mutations to 6-thioguanine resistance describe cumulative curves which reveal nonthreshold responses for both radiations. Although neither of these curves is linear over the entire range of doses shown, the initial portions of both curves are linear with non-zero slopes. The linear slopes for ..cap alpha..- and x-ray-induced mutations are 4.79 +- 0.50 and 1.30 +- 0.23 x 10/sup -7/ mutations per viable cell per rad, respectively. However, plots of mutation frequency against survival show that for a given level of survival, ..cap alpha.. radiation is relatively less mutagenic than is x radiation.

Research Organization:
Los Alamos Scientific Lab., NM
OSTI ID:
5366423
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 80:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
HEAVY NUCLEI
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
ISOTOPES
MAMMALS
MUTAGENESIS
MUTATION FREQUENCY
MUTATIONS
NESDPS Office of Nuclear Energy Space and Defense Power Systems
NUCLEI
NUMERICAL DATA
PLUTONIUM 238
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY
RODENTS
SURVIVAL CURVES
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES