Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells (CHO/HGPRT system)

Journal Article · Wed Dec 31 23:00:00 EST 1980 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860030306· OSTI ID:5336529

O'Neill, J P; Forbes, N L; Hsie, A W

The cytotoxicity and mutagenicity of the fungicides captan and folpet were determined in the CHO/HGPRT system which utilizes Chinese hamster ovary cells and resistance to 6-thioguanine to estimate mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus. Treatment of cultures with each compound for 5 hr in serum-free medium resulted in reproducible, significant, concentration-dependent increases in the frequency of 6-thioguanine-resistant mutants.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5336529
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 3; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL CULTURES
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
FEMALE GENITALS
FUNGICIDES
GONADS
HAMSTERS
MAMMALS
MUTAGENESIS
MUTANTS
ORGANS
OVARIES
PESTICIDES
RODENTS
VERTEBRATES