Mutagenicity and cytotoxicity of ethylene oxide in the CHO/HGPRT system

Journal Article · Wed Dec 31 23:00:00 EST 1980 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860030610· OSTI ID:5336544

Tan, E L ^[1]; Cumming, R B; Hsie, A W

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1. Univ. of Tennessee, Oak Ridge

Ethylene oxide (EO) is made on an industrial scale (2.5 billion pounds per year) and is used not only to prepare a number of commercially important compounds but also as a widely used fumigant to sterilize foodstuffs, textiles, and medical instruments. EO is an alkylating agent that has been shown to interact with proteins and nucleic acids and is mutagenic in a number of test systems, eg, rodents, bacteria, rice, and Drosophila. Reported is the cytotoxicity and mutagenicity of EO in a mammalian cel culture system, the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase (CHO/HGPRT) system.

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5336544
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 3:6; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKENES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL CULTURES
CHALCOGENIDES
DIGESTIVE SYSTEM
ETHYLENE
FEMALE GENITALS
GLANDS
GONADS
HAMSTERS
HOMOGENATES
HYDROCARBONS
LIVER
MAMMALS
METABOLIC ACTIVATION
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANS
OVARIES
OXIDES
OXYGEN COMPOUNDS
RATS
RODENTS
VERTEBRATES